Our aim was to investigate the extent of white matter tissue damage in patients with early alzheimer disease ad using diffusion tensor magnetic resonance imaging dti. Diffusion tensor imaging in early alzheimers disease. High resolution diffusion tensor imaging in parkinsons. For the purpose of this study, all subjects were grouped into either normal and nonncv slowing,10 m sec or ncv slowing 10 msec. To date, frequently inconsistent results have been reported, though lack of standardisation in acquisition and analysis make such discrepancies difficult to interpret. This image, visualized in our neuroimaging software suite, brainmagix, displays an overview of the brains main white matter bundles. Pilot study on therapeutic inhalation of hydrogen gas for. The only way that diffusion tensor imaging can be performed is with a 3. Combined diffusion tensor imaging and arterial spin labeling. This work elucidates the impact of incorporating data from different imaging modalities. Introduction to diffusion tensor imaging mathematics. The scientific plan is to test the global hypothesis that selected measures derived from diffusion tensor imaging provide a highly sensitive and specific, noninvasive trait biomarker of. Article applications of diffusion tensor imaging and. Mri scans using diffusion tensor imaging can predict alzheimers disease.
Diffusion tensor imaging was used to test the hypothesis that the microstructural integrity of superior frontal and temporal white matter, one of the last regions to mature, would be reduced in vivo in early. Diffusion tensor imaging for alzheimers disease scielo. Fuse multimodal brain images, from any mri, ct, or pet scanner surfermagix module. Potential role of diffusion tensor mri in the differential diagnosis of mild cognitive impairment and alzheimers disease daniella b. The purpose of this project is to further develop diffusion tensor imaging as a noninvasive trait biomarker for parkinsons disease.
Update on diffusion tensor imaging in alzheimers disease. Conductivity tensor imaging cti utilizes b1 mapping and multib diffusion weighted mri to produce lowfrequency anisotropic conductivity tensor images without injecting current. Diffusion tensor imaging of a brain with alzheimer s diffusion tensor imaging dti shows the direction of water molecules along brain neurons, the direction of which are differentiated by color. Potential role of diffusion tensor mri in the differential diagnosis. An unbiased longitudinal analysis framework for tracking white matter changes using diffusion tensor imaging with application to alzheimers disease. Usefulness of diffusion tensor imaging of white matter in. Diffusion tensor imaging is a method in which we can measure how water moves along the nerves or what is called fa or fractional anisotropy. Alzheimers disease diagnosis from diffusion tensor images.
Quantify the atrophy of the brain and its structures fmri module. Functional imagingnuclear medicine techniques structural mri vbm ftd rsfmri, zhou, 2010. Applications of diffusion tensor imaging and fiber tractography. Frontiers is diffusion tensor imaging a good biomarker. Gray and white matter changes in alzheimers disease. Diffusion tensor metrics as biomarkers in alzheimers disease plos. An objective and valid trait and state biomarker of parkinsons disease will help therapeutic development by providing a measure to help confirm diagnosis trait, and track disease progression state. The potential contribution of dti diffusion tensor imaging to an early and more accurate diagnosis of neurodegenerative diseases has received increasing attention over the last years. The european dti study on dementia a multicenter dti and. Background although diffusion tensor imaging has been a major research. Diffusion tensor imaging dti is a sophisticated mribased neuroimaging technique that enables in vivo quantification of differences in molecular diffusion at the cellular level. An axial view of diffusion tractography of a single subject. This paper aimed to assess brain gray gm and white matter wm abnormalities jointly to elucidate differences in abnormal mri patterns between the diseases.
The dti data were postprocessed with dti task card software. We use cookies to offer you a better experience, personalize content, tailor advertising, provide social media features, and better understand the use of our services. Joint assessment of structural, perfusion, and diffusion. Mri scans using diffusion tensor imaging dti show potential for predicting if a patient will develop alzheimer s disease later in life, according to findings to be presented at rsna 2018 in chicago. Mri exams of the brain using diffusion tensor imaging dti are a promising option for analysis of dementia risk. While there are huge number of reports in the gray matter changes in alzheimers disease ad, there are also increasing number of reports on white matter changes in the cases of ad due to the development of diffusion tensor methods. Mri diffusion tensor imaging may predict onset of alzheimers.
Diffusion tensor imaging dti studies are increasingly popular among. Software toolbox for lowfrequency conductivity and. The aim of this study was to assess the intersite variability after harmonization of a highangularresolution 3t diffusion tensor imaging protocol across scanners at the 11 academic. Effectiveness of regional dti measures in distinguishing alzheimers. The postprocessing software, functool, was used to measure fa and md. Diffusion tensor imaging dti is one of the mri techniques that can measure the. White matter changes in preclinical alzheimers disease. Diffusion tensor imaging of brains of alzheimer patients. Tbsspart of fmribs software library or fsl smith et al. Agerelated decline in brain white matter anisotropy measured with spatially corrected echoplanar diffusion tensor imaging. Diffusion tensor imaging dti shows the direction of water molecules along brain neurons, the direction of which are differentiated by color. January 7, 2010 diffusion tensor imaging dti better detects whether a person with memory loss might have brain changes of alzheimers disease than traditional magnetic resonance imaging mri, according to a new study published in the january 6, 2010, online issue of neurology. Amlien ik, fjell am 2014 diffusion tensor imaging of white matter degeneration in alzheimer s disease and mild cognitive impairment.
Our study aimed to explore any differences in the microstructural changes to the fornices of inph and ad patients relative to those of normal control subjects, as demonstrated by using diffusion tensor imaging dti. For this reason, we see patients from all over the region who are looking to determine the extent. Several investigators have suggested that the pathological progression of alzheimers disease appears to recapitulate the developmental maturation pattern, a process termed retrogenesis. Diffusion tensor imaging or dtian imaging technique capable of probing white matter. Comparison of neuropsychiatric symptoms and diffusion tensor. Twentyfour patients with sivd and 32 with ad were recruited. Diffusion tensor imaging of neuropsychiatric symptoms in. Twenty patients with alzheimer disease, 20 with vascular dementia, and 10 control subjects were examined. This technique allows one to directly measure several unique aspects of bulk tissue microstructure by mapping water proton motion within the tissue microenvironment 8, 9.
Diffusion tensor imaging of a brain with alzheimers. Diffusion tensor imaging in preclinical and presymptomatic. Diffusion tensor imaging of neuropsychiatric symptoms in mild cognitive impairment and alzheimers dementia. Subjects included 15 patients with ad 11 women and 4 men. Diffusion tensor imaging to understand pd pathophysiology.
Differences in microstructural alterations of the hippocampus. Diffusion tensor imaging of normalappearing white matter in mild. Diffusion tensor imaging dti, an imaging technique used to assess the integrity and connectivity of wm, has been used to study neuropsychiatric disorders. The neurography institute is the worlds leading expert source for diffusion tensor imaging. Although, the value of dti is likely to be greatest for assessing white matter degeneration in alzheimers disease ad, crosssectional dti studies consistently show increased diffusivity in gray matter regions that are typically involved with the. Our aim was to determine whether diffusion anisotropy and diffusivity of white matter tracts of the temporal stem in patients with alzheimer ad can be evaluated independently by using diffusion tensor tractography. Methods data were drawn from the pubmed database using the search terms alzheimers disease and diffusion magnetic resonance imaging. Diffusion tensor imaging dti is an mri technique that uses anisotropic diffusion to estimate the axonal white matter organization of the brain. Structure and biomarkers microstructural changes in the brain that occur in the fatal neurodegenerative disorder alzheimer s disease have been detected using. Diffusion tensor imaging investigations in alzheimers. Fiber tractography ft is a 3d reconstruction technique to assess neural tracts using data collected by diffusion tensor imaging. The structural images were visually inspected for any structural abnormalities by a neuroimaging expert.
Diffusion tensor imaging applied diffusion gradient encoding in six non. For processing the dti, all imaging data were transferred to a cluster of linux workstations. These exams assess the condition of the brains white matter. Dti scans in adni2 provide numerous biomarkers of alzheimers disease. Using local maps of aggregates avg, std, iqr, fractal dimension of the rd, md, fa and others registration of the brains and calculation of statistical differences.
Persons destined to develop the disease by virtue of fully penetrant genetic alterations familial alzheimers disease or fad provide a model in which early and even presymptomatic changes of the disease may be identified. Image analysis dti postprocessing and quantitative analysis were performed with a work. Diffusion tensor imaging of neuropsychiatric symptoms in mild. Diffusion tensor imaging dti fiber tracking imagilys. Frontiers diffusion tensor imaging in alzheimers disease. Diffusionweighted imaging dwi is based on the measurement of thermal brownian motion of water molecules. Although ad pathology mainly affects cortical grey matter, previous magnetic resonance imaging mri studies showed that changes also exist in the white matter wm.
Chua tc, wen w, slavin mj, sachdev ps 2008 diffusion tensor imaging in mild cognitive impairment and alzheimer s disease. Comparison of neuropsychiatric symptoms and diffusion. Diffusion tensor imaging dti is an mribased neuroimaging technique which makes it possible to estimate the location, orientation, and anisotropy of the brains white matter tracts. Frontiers is diffusion tensor imaging a good biomarker for. Only one study has examined dti correlates of neuropsychiatric symptoms in ad. Diffusion tensor imaging dti measures the random motion of water in cerebral tissue. This study aimed to identify a pdspecific mri pattern using combined diffusion tensor imaging dti and arterial spin labeling asl to discriminate patients with early pd. If a disruption in the water pathway is detected, we know that there is an injury or damage in that specific area of the brain. Diffusionweighted magnetic resonance imaging dwi or dwmri is the use of specific mri sequences as well as software that generates images from the resulting data that uses the diffusion of water molecules to generate contrast in mr images. Diffusion tensor imaging in dementia howard rosen ucsf department of neurology memory and aging center. Effectiveness of diffusion tensor imaging in differentiating early. Dti allows in vivo examination of the orientation and microstructural integrity of the wm by measuring fa and md. Doctors imaging is the only facility in the gulf south. Alzheimers disease ad is a neurodegenerative disorder.
The oxford centre for functional mri of the brain fmrib software. Although, the value of dti is likely to be greatest for assessing white matter degeneration in alzheimer s disease ad, crosssectional dti studies consistently show increased diffusivity in gray matter regions that are typically involved with the. Diffusion tensor metrics as biomarkers in alzheimers. Alzheimers disease, corpus callosum, diffusion tensor imaging, fractional. The value of dti in the investigation of brain tumors and metabolic disorders is assessed. Diffusion tensor imaging and fiber tractography radiology. Most mri studies of alzheimers disease ad and frontotemporal dementia ftd have assessed structural, perfusion and diffusion abnormalities separately while ignoring the relationships across imaging modalities. Diffusion tensor imaging was used to test the hypothesis that the microstructural integrity of superior frontal and temporal white matter, one of the last regions to mature, would be reduced in vivo in early alzheimers disease. Overview examples of dti findings in alzheimers disease. Diffusion tensormri better detects early signs of alzheimers. Precision medicine is an approach to disease diagnosis, treatment, and prevention that relies on quantitative biomarkers that minimize the variability of individual patient measurements. Dti is an approach used to estimate changes in white matter integrity, which makes it possible to study the structure of cerebral tissue, such as the trajectories in white matter bundles and the orientation of fibers conturo et al. Frontal executive function in vascular cognitive impairment stephen salloway, md stephen correia, phd paul malloy, phd william heindel, phd david laidlaw, phd goal to develop diffusiontensor imaging as an imaging biomarker of white matter integrity in aging and dementia research focus frontal systems disruption. Nestor brain plasticity and neurodegeneration group, german center for neurodegenerative diseases dzne, magdeburg, germany.
To evaluate the usefulness of diffusion tensor imaging in detecting the water diffusivity caused by neuropathological change in alzheimer disease and vascular dementia. Brainmagix combines the most advanced neuroimaging techniques into a unified, vendorneutral, and clinicallyoriented software suite. Diffusion anisotropy and diffusivity of white matter. Diffusion tensor imaging dti is a magnetic resonance imaging technique that enables the measurement of the restricted diffusion of water in tissue in order to produce neural tract images instead of using this data solely for the purpose of assigning contrast or colors to pixels in a crosssectional image. This report summarizes the recent knowledge about white matter lesions in alzheimers disease. Mri scans using diffusion tensor imaging can predict. Objective to describe and compare diffusion tensor imaging dti parameters between.
Diffusion tensor imaging dti provides information on tissue microstructure that is different from conventional t1 and t2weighted mri. Anisotropic diffusion may be decribed in terms of an ellipsoid tensor. Aug 21, 2018 diffusion tensor imaging dti is a valuable tool to assess white matter wm abnormalities, and it can be used in the longitudinal assessment of patients as well as markers of disease progression and treatment response 7, 8. Diffusion tensor imaging enables mapping of white matter microstructure changes in development, aging and neurological disorders, from the tensor, its possible to derive the mean diffusivity dm and the fractional anisotropy fa which is the most robust measures of anisotropy which measure the degree of deviation from isotropic diffusion. Backgroundalthough diffusion tensor imaging has been a major research focus for alzheimers disease in recent years, it remains unclear whether it has sufficient stability to have biomarker potential. Joint assessment of structural, perfusion, and diffusion mri. The present study aimed to i compare bpsd between patients with subcortical ischemic vascular disease sivd and alzheimers disease ad across stages, and ii explore the associations with diffusion tensor imaging dti in the corpus callosum cc and other major fibers. Application of diffusion tensor imaging in alzheimers. Preprocessing and analyses of diffusion data were done with an inhouse protocol using fmrib software library fsl, version 5. Dti analyses and clinical applications in alzheimers disease. Dti can be used to assess the degradation of wm tracts by measuring the fa and md. Alzheimers disease and the fornix view all 11 articles. The post processing software, functool, was used to measure fa and md.
It allows the mapping of the diffusion process of molecules, mainly water. A novel mri methoddiffusion tensor imagingwas used to compare the integrity of several white matter fibre tracts in patients with probable alzheimers disease. Download citation diffusion tensor imaging in alzheimers disease diffusion tensor imaging dti provides information on tissue microstructure that is different from conventional t1 and t2. Although alzheimers disease ad and vascular cognitive. White matter of s1 frontal the green fiber tracts shown are the neurons of the primary somatosensory cortex s1 which are functionally involved in processing signals from the gi tract.
Diffusion tensor imaging dti and neuropsychological data were. In contrast, only a few studies reported on hydrocephalus by using the dti technique. In this study we performed diffusion tensor imaging dti on 2 demented and 21 subjects atrisk for inheriting an fad. Decreased faincreased md values in the ad hippocampus have been reported by many studies.
Amlien ik, fjell am 2014 diffusion tensor imaging of white matter degeneration in alzheimers disease and mild cognitive impairment. Quantification of white matter microstructural changes the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Diffusion tensor imaging provides much more data about the condition of the brain than a conventional mri, allowing a doctor to clearly see areas of concern. Relationship between dti metrics and cognitive function. The fornix is an important structure in the memory function, and damage to the fornix can result in memory impairment. Toward precision and reproducibility of diffusion tensor. Current mr imaging technology has made possible the in vivo assessment of white matter integrity by means of diffusiontensor dt imaging. Mar 25, 2020 this medical imaging technique is also used in diagnosis, especially when stroke or multiple sclerosis are suspected.
The patient will be asked to remove all jewelry and metal, commonly changing into a hospital gown to reduce the risk of forgetting about a metal rivet, button, or snap, and then he. Potential role of diffusion tensor mri in the differential. It is based on the measurement of the random motion of water molecules. Diffusion tensor imaging archives doctors imaging 3t. Most mri studies of alzheimer s disease ad and frontotemporal dementia ftd have assessed structural, perfusion and diffusion abnormalities separately while ignoring the relationships across imaging modalities. Owing to the highly directional architecture of white matter wm, dti is providing important clues of the structure and geometric organization of this neural. Structural mr imaging studies on alzheimer disease ad and mild cognitive. Diffusion tensor imaging in alzheimers disease mayo clinic. Brain injury when a routine brain mri shows no abnormality dti can often reveal the actual injury that is invisible on standard mri why is this. Jul 28, 2017 the present study aimed to i compare bpsd between patients with subcortical ischemic vascular disease sivd and alzheimers disease ad across stages, and ii explore the associations with diffusion tensor imaging dti in the corpus callosum cc and other major fibers. The toolbox functions were tested by using several experimental data sets which are provided together with the toolbox.
Chua tc, wen w, slavin mj, sachdev ps 2008 diffusion tensor imaging in mild cognitive impairment and alzheimers disease. In elderly patients with dementia and with dilated ventricles, it is often difficult to. Application of diffusion tensor imaging in alzheimers disease. Combined diffusion tensor imaging and arterial spin. In ad, histologic evidence shows early microstructural white matter changes brun and englund, 1986. Neuroimaging studies using diffusion tensor imaging dti have shown increased diffusivity e. When a diffusion tensor imaging study is ordered, the patient needs to go to a facility which has an mri machine and the software to create a diffusion tensor image.
Image processing is of vital importance in dti with numerous programs available to users that provide a computerized approach for tensor calculation, color. Persons destined to develop the disease by virtue of fully penetrant genetic alterations familial alzheimer s disease or fad provide a model in which early and even presymptomatic changes of the disease may be identified. Sep 20, 2016 this study aimed to identify a pdspecific mri pattern using combined diffusion tensor imaging dti and arterial spin labeling asl to discriminate patients with early pd from healthy subjects. Localize eloquent brain areas for neurosurgical planning.
1687 873 637 616 1226 842 74 1455 982 1573 517 1164 488 1614 1097 701 1027 579 296 1329 974 469 1543 1332 788 1169 1472 990 1053 550 1028 449 1328